Article
Kif1C, a kinesin-like motor protein, mediates mouse macrophage resistance to anthrax lethal factor.
Current biology : CB - 2 Oct 2001
Watters J W, Dewar K, Lehoczky J, Boyartchuk V, Dietrich W F
Abstract excerpt
BACKGROUND: Inbred mouse strains exhibit striking differences in the susceptibility of their macrophages to the effects of anthrax lethal toxin (LeTx). Previous data has shown that this difference in susceptibility lies downstream of toxin entry into macrophages. A locus controlling this phenotype, called Ltxs1, has been mapped to chromosome 11, but the responsible gene has not been identified. RESULTS: Here, we...
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