Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

A new class of bacterial RNA polymerase inhibitor affects nucleotide addition.

Science (New York, N.Y.) - 24 Oct 2003

Artsimovitch Irina, Chu Clement, Lynch A Simon, Landick Robert

Abstract excerpt

RNA polymerase (RNAP) is the central enzyme of gene expression. Despite availability of crystal structures, details of its nucleotide addition cycle remain obscure. We describe bacterial RNAP inhibitors (the CBR703 series) whose properties illuminate this mechanism. These compounds inhibit known catalytic activities of RNAP (nucleotide addition, pyrophosphorolysis, and Gre-stimulated transcript cleavage) but not...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to DNA-Directed RNA Polymerases
Share to Exodeoxyribonucleases
Share to Hydroxylamines

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Nucleotides

Share to Phenylurea Compounds

Share to Piperazines

Share to Pyrazoles

Share to Templates, Genetic

Source

Identifiers

PMID: 14576436
DOI: 10.1126/science.1087526

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A new class of bacterial RNA polymerase inhibitor affects nucleotide addition.PMID 14576436Read ↗

Transcription inhibition by the depsipeptide antibiotic salinamide A.Semantic proximity Read ↗

Mutations in RNA Polymerase Bridge Helix and Switch Regions Affect Active-Site Networks and Transcript-Assisted Hydrolysis.Semantic proximity Read ↗

Activity map of the Escherichia coli RNA polymerase bridge helix.Semantic proximity Read ↗

A bridge to transcription by RNA polymerase.Semantic proximity Read ↗

A mutation in RNA polymerase imparts resistance to β-lactams by preventing dysregulation of amino acid and nucleotide metabolism.Semantic proximity Read ↗

Chemical biology of DNA polymerases: from selectivity to new functions.Semantic proximity Read ↗

Allosteric control of catalysis by the F loop of RNA polymerase.Semantic proximity Read ↗

Structural, functional, and genetic analysis of sorangicin inhibition of bacterial RNA polymerase.Semantic proximity Read ↗

Structural basis for the unexpected activity of rifamycin B against rifampicin-resistant RNA polymeraseSemantic proximity Read ↗

Retro-Inversion Imparts Antimycobacterial Specificity to Host Defense PeptidesSemantic proximity Read ↗

The antibiotic sorangicin A inhibits promoter DNA unwinding in a Mycobacterium tuberculosis rifampicin-resistant RNA polymeraseSemantic proximity Read ↗

Mutations in the CRE pocket of bacterial RNA polymerase affect multiple steps of transcription.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.