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Article

Structural, functional, and genetic analysis of sorangicin inhibition of bacterial RNA polymerase.

The EMBO journal - 23 Feb 2005

Campbell Elizabeth A, Pavlova Olga, Zenkin Nikolay, Leon Fred, Irschik Herbert, Jansen Rolf, Severinov Konstantin, Darst Seth A

Abstract excerpt

A combined structural, functional, and genetic approach was used to investigate inhibition of bacterial RNA polymerase (RNAP) by sorangicin (Sor), a macrolide polyether antibiotic. Sor lacks chemical and structural similarity to the ansamycin rifampicin (Rif), an RNAP inhibitor widely used to treat tuberculosis. Nevertheless, structural analysis revealed Sor binds in the same RNAP beta subunit pocket as Rif, with...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 15692574
DOI: 10.1038/sj.emboj.7600499
PMCID: PMC549610

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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