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Article

Retro-Inversion Imparts Antimycobacterial Specificity to Host Defense Peptides

2025-05-05

Abstract excerpt

<title>Abstract</title> <p> Antimicrobial host defense peptides are promising alternatives to resistance prone small molecule antibiotics. To overcome the poor physiologic stability of these therapeutic candidates it is common to prepare proteolytically resistant retro-inverso analogues, where sequence backbone direction and amino acid chirality are reversed. However, in many cases, gains in stability are offset...

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Literature Corpus work
3dcfdafc-6645-5d70-8660-08e22d517b4e
DOI
10.21203/rs.3.rs-6497899/v1
Open publication

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Retro-Inversion Imparts Antimycobacterial Specificity to Host Defense PeptidesDOI 10.21203/rs.3.rs-6497899/v1
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