Article
Polymorphisms in the MTHFR gene are associated with breast cancer.
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine - 1 Jan 2000
Ergul Emel, Sazci Ali, Utkan Zafer, Canturk N Zafer
Abstract excerpt
The methylenetetrahydrofolate reductase (MTHFR) gene is a polymorphic gene involved in folate metabolism, DNA biosynthesis, methylation and genomic integrity in actively dividing cells. The MTHFR C677T and A1298C polymorphisms are likely to play an important role in the susceptibility to breast c...
Topics
- Adult
- Breast Neoplasms
- Case-Control Studies
- Female
- Gene Frequency
- Genotype
- Humans
- Methylenetetrahydrofolate Reductase (NADPH2)
- Polymorphism, Genetic
- Premenopause