Article
MTHFR 677C>T polymorphism and the risk of breast cancer: evidence from an original study and pooled data for 28031 cases and 31880 controls.
PloS one - 1 Jan 2015
Pooja Singh, Carlus Justin, Sekhar Deepa, Francis Amirtharaj, Gupta Nishi, Konwar Rituraj, Kumar Sandeep, Kumar Surender, Thangaraj Kumarasamy, Rajender Singh
Abstract excerpt
BACKGROUND: Methylenetetrahydrofolate reductase (MTHFR) acts at an important metabolic point in the regulation of cellular methylation reaction. It assists in the conversion of 5, 10-methylenetetrahydrofolate to 5-methyltetrahydrofolate. The latter aids in remethylation of homocysteine to de novo methionine that is required for DNA synthesis. The objective of this study was to examine the effect of MTHFR 677 C>T...
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