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Article

A common mutation in methylenetetrahydrofolate reductase gene is not a major risk of coronary artery disease or myocardial infarction.

Atherosclerosis - 3 Jan 1997

Brugada R, Marian A J

Abstract excerpt

A common mutation (C677-->T) in methylenetetrahydrofolate (MTHFR) gene, involved in the metabolism of homocysteine, has been suggested to play a role in increasing cardiovascular disease risk. We determined the frequency of C677-->T genotypes and alleles in 155 Caucasian patients with angiographically documented coronary artery disease (CAD) and in 155 age and sex matched normal Caucasian individuals. DNA was...

Read the complete abstract on PubMed

Topics

Alleles
Coronary Disease
Female
Genotype
Humans
Male
Methylenetetrahydrofolate Reductase (NADPH2)

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Middle Aged

Myocardial Infarction

Oxidoreductases Acting on CH-NH Group Donors

Point Mutation

Polymerase Chain Reaction

Risk Factors

Source

Identifiers

PMID: 9051203
DOI: 10.1016/s0021-9150(96)05977-1

Genes

CAD
MTHFR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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