Article
Mutations of the p53 gene in gliomas from Malay patients.
The Medical journal of Malaysia - 1 Jun 2003
Jafri A, Aziz M Y, Ros S, Nizam I
Abstract excerpt
This is the first investigation performed to detect the presence of the p53 mutation in Malay patients with gliomas. The p53 gene was amplified using polymerase chain reaction (PCR) from 33 fresh-frozen tumour tissues from patients histologically confirmed as glioma. Four hot spot areas that lie between exon 5 to 8 were screened for mutation by mean of non-isotopic "cold" single strand conformation polymorphism...
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