Article
TP53 mutations in salivary gland neoplasms.
Brazilian dental journal - 1 Jan 2005
Matizonkas-Antonio Luciana Fasanella, de Mesquita Ricardo Alves, de Souza Suzana C Orsini Machado, Nunes Fabio Daumas
Abstract excerpt
Many studies have demonstrated that loss of TP53 gene function has an important role in the genesis of many neoplasms, including salivary gland neoplasms. The purpose of this study was to examine the mutation profile of the TP53 gene in salivary gland neoplasms. Genomic DNA was extracted from paraffin-embedded tissues of pleomorphic adenoma, carcinoma in pleomorphic adenoma, mucoepidermoid carcinoma, adenoid...
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