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Article

Molecular determinants of proton modulation of glycine receptors.

The Journal of biological chemistry - 9 Jan 2004

Chen Zhenglan, Dillon Glenn H, Huang Renqi

Abstract excerpt

Extracellular pH regulates glycine receptors through an unknown mechanism. Here we demonstrate that acidic pH remarkably inhibited glycine-activated whole-cell currents in recombinant glycine alpha1 and alpha1beta receptors transiently expressed in human embryonic kidney 293 cells. The proton effect was voltage-independent and pharmacologically competed with glycine receptor agonist glycine and antagonist...

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Identifiers

PMID: 14563849
DOI: 10.1074/jbc.M307684200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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