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Article

Characterization of the effects of charged residues in the intracellular loop on ion permeation in alpha1 glycine receptor channels.

The Journal of biological chemistry - 23 Jan 2009

Carland Jane E, Cooper Michelle A, Sugiharto Silas, Jeong Hyo-Jin, Lewis Trevor M, Barry Peter H, Peters John A, Lambert Jeremy J, Moorhouse Andrew J

Abstract excerpt

The Cys loop receptor channels mediate fast synaptic transmission in the nervous system. The M2-demarcated transmembrane pore is an important determinant of their ion permeation properties. Portals within the intracellular domain are also part of the permeation pathway in cationic Cys loop receptors, with charged residues in a helical MA stretch partially lining these openings profoundly affecting channel...

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PMID: 19049967
DOI: 10.1074/jbc.M806618200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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