Article
Kinetics and functional characterization of the glycine receptor alpha2 and alpha3 subunit.
Neuroscience letters - 11 Dec 2007
Heindl Cornelia, Brune Kay, Renner Bertold
Abstract excerpt
In recent studies one serine residue (Ser-346) within the protein-kinase-A (R-E-S-R) consensus sequence of the GlyRalpha3 intracellular loop has proven to be an essential target for prostaglandin-E(2)-mediated phosphorylation, which further modulates spinal nociceptive transmission and central inflammatory pain sensitization. In the present study we investigated the effect of Ser-346 phosphorylation and Ser-346...
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