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Article

Exploring the Activation Process of the Glycine Receptor.

Journal of the American Chemical Society - 25 Sept 2024

Yan Junfang, Chen Luonan, Warshel Arieh, Bai Chen

Abstract excerpt

Glycine receptors (GlyR) conduct inhibitory glycinergic neurotransmission in the spinal cord and the brainstem. They play an important role in muscle tone, motor coordination, respiration, and pain perception. However, the mechanism underlying GlyR activation remains unclear. There are five potential glycine binding sites in α1 GlyR, and different binding patterns may cause distinct activation or desensitization...

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Identifiers

PMID: 39279763
DOI: 10.1021/jacs.4c08489
PMCID: PMC12393165

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

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