Article
Role of charged residues in coupling ligand binding and channel activation in the extracellular domain of the glycine receptor.
The Journal of biological chemistry - 12 Dec 2003
Absalom Nathan L, Lewis Trevor M, Kaplan Warren, Pierce Kerrie D, Schofield Peter R
Abstract excerpt
The glycine receptor is a member of the ligand-gated ion channel receptor superfamily that mediates fast synaptic transmission in the brainstem and spinal cord. Following ligand binding, the receptor undergoes a conformational change that is conveyed to the transmembrane regions of the receptor resulting in the opening of the channel pore. Using the acetylcholine-binding protein structure as a template, we...
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