Article
Molecular determinants of proton-sensitive N-methyl-D-aspartate receptor gating.
Molecular pharmacology - 1 Jun 2003
Low Chian-Ming, Lyuboslavsky Polina, French Adam, Le Phuong, Wyatte Karen, Thiel William H, Marchan Edward M, Igarashi Kazuei, Kashiwagi Keiko, Gernert Kim, Williams Keith, Traynelis Stephen F, Zheng Fang
Abstract excerpt
Extracellular protons inhibit N-methyl-D-aspartate (NMDA) receptors with an IC50 value in the physiological pH range. To identify the molecular determinants of proton sensitivity, we used scanning mutagenesis of the NR1 subunit to search for residues that control proton inhibition of NMDA receptors. Homology modeling of the extracellular domains suggested that residues at which mutations perturbed pH sensitivity...
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