Article
Intracellular location and cell context-dependent function of protein kinase D.
Immunity - 1 Oct 2003
Marklund Ulrica, Lightfoot Kurt, Cantrell Doreen
Abstract excerpt
Protein kinase D (PKD) is an antigen receptor-activated serine kinase localized at either the plasma membrane or the cytosol of lymphocytes. To probe PKD function at these different locations, transgenesis was used to target active PKD either to the membrane or cytosol of pre-T cells. In recombinase gene null pre-T cells, membrane and cytosolic active PKD both induced differentiation reminiscent of beta...
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