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Article

Cutting edge: a chemical genetic system for the analysis of kinases regulating T cell development.

Journal of immunology (Baltimore, Md. : 1950) - 15 Jul 2003

Denzel Angela, Hare Katherine J, Zhang Chao, Shokat Kevan, Jenkinson Eric J, Anderson Graham, Hayday Adrian

Abstract excerpt

To understand the regulatory activities of kinases in vivo requires their study across a biologically relevant window of activity. To this end, ATP analog-sensitive kinase alleles (ASKAs) specifically sensitive to a competitive inhibitor have been developed. This article tests whether ASKA technology can be applied to complex immunological systems, such as lymphoid development. The results show that when applied...

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Share to Adenosine Triphosphate
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Lymphocyte Specific Protein Tyrosine Kinase p56(lck)

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Share to Retroviridae

Share to Thymus Gland

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Source

Identifiers

PMID: 12847211
DOI: 10.4049/jimmunol.171.2.519

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