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Article

Protein kinase D1 and the beta 1 integrin cytoplasmic domain control beta 1 integrin function via regulation of Rap1 activation.

Immunity - 1 Aug 2005

Medeiros Ricardo B, Dickey Deborah M, Chung Heekyoung, Quale Angie C, Nagarajan Lakshmi R, Billadeau Daniel D, Shimizu Yoji

Abstract excerpt

The functional activity of integrins is dynamically regulated by T cell receptor stimulation and by protein kinase C (PKC). We report a novel function for the PKC effector protein kinase D1 (PKD1) in integrin activation. Constitutively active and kinase-inactive PKD1 mutants lacking the PKD1 pleckstrin homology (PH) domain block phorbol ester- and TCR-mediated activation and clustering of beta1 integrins. The PH...

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Source

Identifiers

PMID: 16111639
DOI: 10.1016/j.immuni.2005.07.006

Genes

PKD1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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