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Article

Dual phospholipase C/diacylglycerol requirement for protein kinase D1 activation in lymphocytes.

The Journal of biological chemistry - 18 Feb 2005

Wood C David, Marklund Ulrica, Cantrell Doreen A

Abstract excerpt

The serine/threonine kinase protein kinase D1 (PKD1) is a protein kinase C (PKC) substrate that mediates antigen receptor signal transduction in lymphocytes. PKC phosphorylates serines 744/748 within the PKD1 catalytic domain, and this is proposed to be necessary and sufficient for enzyme activation. Hence, a PKD1 mutant with alanine substituted at positions 744 and 748 (PKD-S744A/S748A) is catalytically...

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Source

Identifiers

PMID: 15590638
DOI: 10.1074/jbc.M411564200

Genes

PKD1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Dual phospholipase C/diacylglycerol requirement for protein kinase D1 activation in lymphocytes.PMID 15590638Read ↗

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