Article
The MAP kinase pathway controls differentiation from double-negative to double-positive thymocyte.
Cell - 26 Jul 1996
Crompton T, Gilmour K C, Owen M J
Abstract excerpt
T cell development is regulated at two major control points where maturation, proliferation, and antigen receptor gene rearrangement are coordinated. Progression through these developmental control points is dependent upon the expression of different forms of the T cell receptor. Here we show that the MAP kinase cascade is a regulator of the differentiation of immature thymocytes from double-negative to...
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