Article
DNA-dependent protein kinase mediates V(D)J recombination via RAG2 phosphorylation.
Journal of biochemistry and molecular biology - 31 May 2007
Hah Young-Sool, Lee Jung Hwa, Kim Deok Ryong
Abstract excerpt
V(D)J recombination, a site-specific gene rearrangement process occurring during the lymphocyte development, begins with DNA double strand breaks by two recombination activating gene products (RAG1/2) and finishes with the repair process by several proteins including DNA-dependent protein kinase (DNA-PK). In this report, we found that RAG2 was specifically phosphorylated by DNA-PK at the 365(th) serine residue,...
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