Article
Loss-of-function phenotype of a PKCθT219A knockin mouse strain.
Cell communication and signaling : CCS - 6 Nov 2019
Thuille Nikolaus, Siegmund Kerstin, Klepsch Victoria, Schörgenhuber Jacqueline, Danklmaier Sarah, Leitges Michael, Baier Gottfried
Abstract excerpt
BACKGROUND: Protein kinase C θ has been established as an important signaling intermediate in T-effector-cell activation and survival pathways by controlling activity of the key transcription factors NF-κB and NFAT. Previous studies identified an activation-induced auto-phosphorylation site at Thr-219, located between the tandem C1 domains of the regulatory fragment in PKCθ, as a structural requirement for its...
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