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Article

COX-2-deficient mice are less prone to MPTP-neurotoxicity than wild-type mice.

Neuroreport - 27 Oct 2003

Feng Zhehui, Li Dongdong, Fung Peter C W, Pei Zhong, Ramsden David B, Ho Shu-Leong

Abstract excerpt

The primary lesion in Parkinson's disease is the death of dopaminergic neurons in the substantia nigra. The role of cyclooxygenase (COX)-2 in the etiology of Parkinson's disease was explored using COX-2 gene knockout mice. Mortality after injection of 1-methyl-4-phenyl-1,2,3,6 tetrahydropyridine (MPTP, a chemical known to cause parkinsonism in humans) in heterozygous COX-2-deficient mice was lower than that in...

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Source

Identifiers

PMID: 14561922
DOI: 10.1097/00001756-200310270-00009

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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