Article
Increased vulnerability of dopaminergic neurons in MPTP-lesioned interleukin-6 deficient mice.
Journal of neurochemistry - 1 Oct 2002
Bolin Laurel M, Strycharska-Orczyk Iwona, Murray Richard, Langston J William, Di Monte Donato
Abstract excerpt
To test the hypothesis that neuroinflammation contributes to dopaminergic neuron death in the MPTP-lesioned mouse, we compared nigrostriatal degeneration in interleukin (IL)-6 (+/+) with IL-6 (-/-) mice. In the absence of IL-6, a single injection of MPTP (30 mg/kg) resulted in significantly greater striatal dopamine depletion than that measured in IL-6 (+/+) mice. The observed dopamine depletion was MPTP dose...
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