Article
A therapeutic role for cyclooxygenase-2 inhibitors in a transgenic mouse model of amyotrophic lateral sclerosis.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology - 1 Apr 2003
Pompl P N, Ho L, Bianchi M, McManus T, Qin W, Pasinetti G M
Abstract excerpt
Recent studies indicate that the proinflammatory enzyme cyclooxygenase (COX)-2, an enzyme involved in inflammatory cascades but also normal neuronal activities, is elevated in the brain and spinal cord of amyotrophic lateral sclerosis (ALS) patients and ALS mouse model systems. On the basis of this evidence, we explored the impact of COX-2 inhibition on the onset and progression of ALS-like disease in the G93A...
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