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Article

Pioglitazone ameliorates the phenotype of a novel Parkinson's disease mouse model by reducing neuroinflammation.

Molecular neurodegeneration - 2 Apr 2016

Pinto Milena, Nissanka Nadee, Peralta Susana, Brambilla Roberta, Diaz Francisca, Moraes Carlos T

Abstract excerpt

BACKGROUND: Parkinson's disease (PD) is a progressive neurodegenerative disorder characterized by motor and non-motor symptoms. The cause of the motor symptoms is the loss of dopaminergic neurons in the substantia nigra with consequent depletion of dopamine in the striatum. Although the etiology of PD is unknown, mitochondrial dysfunctions, including cytochrome c oxidase (Complex IV) impairment in dopaminergic...

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Identifiers

PMID: 27038906
DOI: 10.1186/s13024-016-0090-7
PMCID: PMC4818913

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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