Article
MPTP and DSP-4 susceptibility of substantia nigra and locus coeruleus catecholaminergic neurons in mice is independent of parkin activity.
Neurobiology of disease - 1 May 2007
Thomas Bobby, von Coelln Rainer, Mandir Allen S, Trinkaus Daniel B, Farah Mohamed H, Leong Lim Kah, Calingasan Noel Y, Flint Beal M, Dawson Valina L, Dawson Ted M
Abstract excerpt
Mutations in the parkin gene cause autosomal recessive familial Parkinson's disease (PD). Parkin-deficient mouse models fail to recapitulate nigrostriatal dopaminergic neurodegeneration as seen in PD, but produce deficits in dopaminergic neurotransmission and noradrenergic-dependent behavior. Since sporadic PD is thought to be caused by a combination of genetic susceptibilities and environmental factors, we...
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