Article

Genetic Deletion of cyclooxygenase-1 ameliorates neuroinflammation and cognitive impairment in 5×FAD mice

2023-02-03

Abstract excerpt

<title>Abstract</title><p><bold>Background:</bold>Neuroinflammation is one of the most important contributing factors for the pathogenesis of Alzheimer’s disease (AD). Cyclooxygenase-1 (COX-1) is distinctly expressed in microglia and involved in microglia activation and neuroinflammation in the AD. However, the molecular mechanisms by which COX-1 regulated microglia activation and participated in AD progression re...

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Literature Corpus work: f418b905-0be2-597f-82a8-216822fab1f5
DOI: 10.21203/rs.3.rs-2522132/v1

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