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Article

Gene-environment interaction models to unmask susceptibility mechanisms in Parkinson's disease.

Journal of visualized experiments : JoVE - 7 Jan 2014

Chou Vivian P, Ko Novie, Holman Theodore R, Manning-Boğ Amy B

Abstract excerpt

Lipoxygenase (LOX) activity has been implicated in neurodegenerative disorders such as Alzheimer's disease, but its effects in Parkinson's disease (PD) pathogenesis are less understood. Gene-environment interaction models have utility in unmasking the impact of specific cellular pathways in toxicity that may not be observed using a solely genetic or toxicant disease model alone. To evaluate if distinct LOX...

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Identifiers

PMID: 24430802
DOI: 10.3791/50960
PMCID: PMC4089441

Genes

LOX
GFAP

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