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Article

Accelerated fat absorption in intestinal alkaline phosphatase knockout mice.

Molecular and cellular biology - 1 Nov 2003

Narisawa Sonoko, Huang Lei, Iwasaki Arata, Hasegawa Hideaki, Alpers David H, Millán José Luis

Abstract excerpt

Intestinal alkaline phosphatase (IAP) is the most ancestral of the tissue-specific members of the AP gene family. Several studies have suggested an absorptive function for IAP, but in vivo data to this effect have been lacking. We inactivated the mouse IAP gene in embryo-derived stem cells and generated mice homozygous for the null mutation. The mice were macroscopically and histologically normal and fertile and...

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Identifiers

PMID: 14560000
DOI: 10.1128/MCB.23.21.7525-7530.2003
PMCID: PMC207564

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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