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Article

The acyl-CoA binding protein is required for normal epidermal barrier function in mice.

Journal of lipid research - 1 Oct 2012

Bloksgaard Maria, Bek Signe, Marcher Ann-Britt, Neess Ditte, Brewer Jonathan, Hannibal-Bach Hans Kristian, Helledie Torben, Fenger Christina, Due Marianne, Berzina Zane, Neubert Reinhard, Chemnitz John, Finsen Bente, Clemmensen Anders, Wilbertz Johannes, Saxtorph Henrik, Knudsen Jens, Bagatolli Luis, Mandrup Susanne

Abstract excerpt

The acyl-CoA binding protein (ACBP) is a 10 kDa intracellular protein expressed in all eukaryotic species. Mice with targeted disruption of Acbp (ACBP(-/-) mice) are viable and fertile but present a visible skin and fur phenotype characterized by greasy fur and development of alopecia and scaling with age. Morphology and development of skin and appendages are normal in ACBP(-/-) mice; however, the stratum corneum...

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PMID: 22829653
DOI: 10.1194/jlr.M029553
PMCID: PMC3435549

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