Article
Generation of mice with a conditional allele for G6pc.
Genesis (New York, N.Y. : 2000) - 1 Sept 2009
Peng Wen-Tao, Pan Chi-Jiunn, Lee Eric J, Westphal Heiner, Chou Janice Y
Abstract excerpt
Glucose-6-phosphatase-alpha (G6Pase-alpha or G6PC) catalyzes the hydrolysis of glucose-6-phosphate to glucose and is a key enzyme in interprandial glucose homeostasis. Mutations in the human G6PC gene, expressed primarily in the liver, kidney, and intestine, cause glycogen storage disease Type Ia...
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