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Mitochondrial DNA polymerase editing mutation, PolgD257A, disturbs stem-progenitor cell cycling in the small intestine and restricts excess fat absorption.

American journal of physiology. Gastrointestinal and liver physiology - 1 May 2012

Fox Raymond G, Magness Scott, Kujoth Gregory C, Prolla Tomas A, Maeda Nobuyo

Abstract excerpt

Changes in intestinal absorption of nutrients are important aspects of the aging process. To address this issue, we investigated the impact of accelerated mitochondrial DNA mutations on the stem/progenitor cells in the crypts of Lieberkühn in mice homozygous for a mitochondrial DNA polymerase gamma mutation, Polg(D257A), that exhibit accelerated aging phenotype. As early as 3-7 mo of age, the small intestine was...

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Identifiers

PMID: 22345551
DOI: 10.1152/ajpgi.00402.2011
PMCID: PMC3362078

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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