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Article

Mutation of the MXI1 gene in prostate cancer.

Nature genetics - 1 Mar 1995

Eagle L R, Yin X, Brothman A R, Williams B J, Atkin N B, Prochownik E V

Abstract excerpt

The Mxi1 protein negatively regulates Myc oncoprotein activity and thus potentially serves a tumour suppressor function. MXI1 maps to chromosome 10q24-q25, a region that is deleted in some cases of prostate cancer. We have detected mutations in the retained MXI1 alleles in four primary prostate tumours with 10q24-q25 deletions. Two tumours contained inactivating mutations, whereas two others contained the...

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Source

Identifiers

PMID: 7773287
DOI: 10.1038/ng0395-249

Genes

MXI1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Mutation of the MXI1 gene in prostate cancer.PMID 7773287Read ↗

Commonly occurring loss and mutation of the MXI1 gene in prostate cancer.Semantic proximity Read ↗

The MXI1 tumor suppressor gene is not mutated in primary prostate cancer.Semantic proximity Read ↗

Loss of the chromosomal region 10q23-25 in prostate cancer.Semantic proximity Read ↗

Molecular analysis of PTEN and MXI1 in primary bladder carcinoma.Semantic proximity Read ↗

Loss of heterozygosity in the MXI1 gene is a frequent occurrence in melanoma.Semantic proximity Read ↗

Role of Mxi1 in ageing organ systems and the regulation of normal and neoplastic growth.Semantic proximity Read ↗

PTEN and MXI1 allelic loss on chromosome 10q is rare in melanoma in vivo.Semantic proximity Read ↗

Mxi1 tumor suppressor gene is not mutated in primary pancreatic adenocarcinoma.Semantic proximity Read ↗

Down-regulation of the KAI1 metastasis suppressor gene during the progression of human prostatic cancer infrequently involves gene mutation or allelic loss.Semantic proximity Read ↗

Allelic loss on chromosome 8p12-21 in microdissected prostatic intraepithelial neoplasia.Semantic proximity Read ↗

<i>KAI1</i> , a Metastasis Suppressor Gene for Prostate Cancer on Human Chromosome 11p11.2Semantic proximity Read ↗

Loss of a small region around the PTEN locus is a major chromosome 10 alteration in prostate cancer xenografts and cell lines.Semantic proximity Read ↗

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