Mutation of the MXI1 gene in prostate cancer.

doi:10.1038/ng0395-249

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Article

Mutation of the MXI1 gene in prostate cancer.

Nature genetics - 1 Mar 1995

Eagle L R, Yin X, Brothman A R, Williams B J, Atkin N B, Prochownik E V

Abstract excerpt

The Mxi1 protein negatively regulates Myc oncoprotein activity and thus potentially serves a tumour suppressor function. MXI1 maps to chromosome 10q24-q25, a region that is deleted in some cases of prostate cancer. We have detected mutations in the retained MXI1 alleles in four primary prostate tumours with 10q24-q25 deletions. Two tumours contained inactivating mutations, whereas two others contained the...

Topics

Alleles
Base Sequence
Basic Helix-Loop-Helix Transcription Factors
Chromosome Aberrations
Chromosome Mapping
Chromosomes, Human, Pair 10
DNA Primers
DNA, Neoplasm
DNA-Binding Proteins
Genes, Tumor Suppressor
Humans

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

In Situ Hybridization, Fluorescence

Male

Molecular Sequence Data

Mutation

Prostatic Neoplasms

Sequence Deletion

Transcription Factors

Source

Open in PubMed

Identifiers

PMID: 7773287
DOI: 10.1038/ng0395-249

Genes

MXI1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7773287-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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Mutation of the MXI1 gene in prostate cancer.PMID 7773287Read ↗

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