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Article

Max interacting protein 1: loss of heterozygosity is frequent in desmoplastic melanoma.

Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc - 1 Apr 1999

Rao U N, Bakker A, Swalsky P A, Finkelstein S D

Abstract excerpt

Max interacting protein 1 (MXI1), a negative regulator of myc oncoprotein with tumor suppressor properties, has been mapped to chromosome 10q24-25. MXI1 gene loss, demonstrated by loss of heterozygosity (LOH) analysis (allelic imbalance), is a frequent event in astrocytomas and other forms of glial neoplasia. Development and progression of malignant melanoma likely involves several cooperative oncogene/tumor...

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Source

Identifiers

PMID: 10229497

Genes

MXI1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Max interacting protein 1: loss of heterozygosity is frequent in desmoplastic melanoma.PMID 10229497Read ↗

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PTEN and MXI1 allelic loss on chromosome 10q is rare in melanoma in vivo.Semantic proximity Read ↗

Microsatellite instability and loss of heterozygosity in melanoma.Semantic proximity Read ↗

Allelic imbalance at NME1 in microdissected primary and metastatic human colorectal carcinomas is frequent but not associated with metastasis to lymph nodes or liver.Semantic proximity Read ↗

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