Lack of expression from a retroviral vector after transduction of murine hematopoietic stem cells is associated with methylation in vivo.

doi:10.1073/pnas.91.7.2567

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Article

Lack of expression from a retroviral vector after transduction of murine hematopoietic stem cells is associated with methylation in vivo.

29 Mar 1994

Abstract excerpt

We describe studies of gene transfer and expression of the human glucocerebrosidase cDNA by a Moloney murine leukemia virus (MoMuLV)-based retroviral vector in a murine gene transfer/bone marrow transplant (BMT) model. Pluripotent hematopoietic stem cells (HSCs) were assayed as the colony-forming units, spleen (CFU-S) generated after serial transplantation. Transcriptional expression from the MoMuLV long-terminal...

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PMID: 8146155
DOI: 10.1073/pnas.91.7.2567

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