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Article

Selection against CpG dinucleotides in lentiviral genes: a possible role of methylation in regulation of viral expression.

Nucleic acids research - 11 Oct 1990

Shpaer E G, Mullins J I

Abstract excerpt

Extremely low frequencies of CpG dinucleotides are found in the genomes of the lentivirus subfamily of retroviruses, including the human, simian and feline immunodeficiency viruses (HIV1, HIV2, SIV, and FIV, respectively), equine infectious anemia virus (EIAV), and the ovine lentivirus, Visna. The occurrence of CpG dinucleotides is greater in the 2-3 (NCG) than in the 1-2 (CGN) codon-defined frame, as well as in...

Topics

Biological Evolution
Codon
Dinucleoside Phosphates
Gene Expression Regulation, Viral
Genes, Viral
Lentivirus
Methylation
Mutation
Phylogeny
Selection, Genetic

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Identifiers

PMID: 2170945
DOI: 10.1093/nar/18.19.5793
PMCID: PMC332316

Genes

CGN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-2170945-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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