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Article

Stochastic dynamics of cancer initiation.

Physical biology - 1 Feb 2011

Foo Jasmine, Leder Kevin, Michor Franziska

Abstract excerpt

Most human cancer types result from the accumulation of multiple genetic and epigenetic alterations in a single cell. Once the first change (or changes) have arisen, tumorigenesis is initiated and the subsequent emergence of additional alterations drives progression to more aggressive and ultimately invasive phenotypes. Elucidation of the dynamics of cancer initiation is of importance for an understanding of...

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Identifiers

PMID: 21301064
DOI: 10.1088/1478-3975/8/1/015002
PMCID: PMC3569097

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