Article
The knockout mouse project.
Nature genetics - 1 Sept 2004
Austin Christopher P, Battey James F, Bradley Allan, Bucan Maja, Capecchi Mario, Collins Francis S, Dove William F, Duyk Geoffrey, Dymecki Susan, Eppig Janan T, Grieder Franziska B, Heintz Nathaniel, Hicks Geoff, Insel Thomas R, Joyner Alexandra, Koller Beverly H, Lloyd K C Kent, Magnuson Terry, Moore Mark W, Nagy Andras, Pollock Jonathan D, Roses Allen D, Sands Arthur T, Seed Brian, Skarnes William C, Snoddy Jay, Soriano Philippe, Stewart David J, Stewart Francis, Stillman Bruce, Varmus Harold, Varticovski Lyuba, Verma Inder M, Vogt Thomas F, von Melchner Harald, Witkowski Jan, Woychik Richard P, Wurst Wolfgang, Yancopoulos George D, Young Stephen G, Zambrowicz Brian
Abstract excerpt
Mouse knockout technology provides a powerful means of elucidating gene function in vivo, and a publicly available genome-wide collection of mouse knockouts would be significantly enabling for biomedical discovery. To date, published knockouts exist for only about 10% of mouse genes. Furthermore, many of these are limited in utility because they have not been made or phenotyped in standardized ways, and many are...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.