Article

Prevalent mouse phenotypes in the unexplored druggable genome

2021-11-08

Abstract excerpt

Among the estimated ~23,000 protein encoding human genes, the class of ‘druggable genes’– defined by their ability to bind drug-like compounds– represents an enticing collection of targets for clinical intervention. Yet many if not most of these genes remain poorly understood and understudied. Here we evaluate three major classes of druggable genes (GPCRs, ion channels, and kinases) and found that a third of these...

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Literature Corpus work: 79f690af-df72-5872-9c57-91f08fca1ce6
DOI: 10.1101/2021.11.08.467777

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