Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Predicting human disease mutations and identifying drug targets from mouse gene knockout phenotyping campaigns

1 May 2019

Abstract excerpt

ABSTRACT Two large-scale mouse gene knockout phenotyping campaigns have provided extensive data on the functions of thousands of mammalian genes. The ongoing International Mouse Phenotyping Consortium (IMPC), with the goal of examining all ∼20,000 mouse genes, has examined 5115 genes since 2011, and phenotypic data from several analyses are available on the IMPC website (www.mousephenotype.org). Mutant mice...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Metabolism, Diabetes, and Cancer
Share to Pancreatic function and diabetes
Share to Pharmacogenetics and Drug Metabolism

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 31064765
DOI: 10.1242/dmm.038224

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Predicting human disease mutations and identifying drug targets from mouse gene knockout phenotyping campaignsPMID 31064765Read ↗

The International Mouse Phenotyping Consortium: comprehensive knockout phenotyping underpinning the study of human disease.Semantic proximity Read ↗

Prevalent mouse phenotypes in the unexplored druggable genomeSemantic proximity Read ↗

Commentary: The International Mouse Phenotyping Consortium: high-throughput in vivo functional annotation of the mammalian genome.Semantic proximity Read ↗

Large Scale Gene Function Discovery to Support Human Health: The International Mouse Phenotyping Consortium (IMPC)Semantic proximity Read ↗

Analysis of mammalian gene function through broad-based phenotypic screens across a consortium of mouse clinics.Semantic proximity Read ↗

Disease model discovery from 3,328 gene knockouts by The International Mouse Phenotyping Consortium.Semantic proximity Read ↗

Mouse large-scale phenotyping initiatives: overview of the European Mouse Disease Clinic (EUMODIC) and of the Wellcome Trust Sanger Institute Mouse Genetics Project.Semantic proximity Read ↗

Knockout mouse models as a resource for the study of rare diseases.Semantic proximity Read ↗

IMPC: Using the mouse phenotpying portalSemantic proximity Read ↗

Investigating gene function and human disease through data on the IMPC portalSemantic proximity Read ↗

High-throughput gene knockouts and phenotyping in mice.Semantic proximity Read ↗

Mutations: Dawn of the Human Knockout Project.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.