Article
In vivo drug target discovery: identifying the best targets from the genome.
Current opinion in biotechnology - 1 Dec 2001
Walke D W, Han C, Shaw J, Wann E, Zambrowicz B, Sands A
Abstract excerpt
A vast number of genes of unknown function threaten to clog drug discovery pipelines. To develop therapeutic products from novel genomic targets, it will be necessary to correlate biology with gene sequence information. Industrialized mouse reverse genetics is being used to determine gene function in the context of mammalian physiology and to identify the best targets for drug development.
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