Article
Single-cell immunohistochemical mutation load assay (SCIMLA) using human paraffin-embedded tissues.
Environmental and molecular mutagenesis - 1 Jan 2003
Schlake Gudrun, Liu Qiang, Heinmöller Ernst, Hill Kathleen A, Weiss Lawrence, Sommer Steve S
Abstract excerpt
It would be advantageous to measure mutation load in situ in order to determine the relationship between a high mutation load and increased risk for cancer or other diseases and to evaluate sources of possible mutagen exposure. Previously, in situ mutation detection assays have been plagued with multiple rounds of amplification and high rates of false-positives and false-negatives. The single cell...
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