p53 as a mutagen test in breast cancer.

doi:10.1002/em.10065

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Article

p53 as a mutagen test in breast cancer.

Environmental and molecular mutagenesis - 1 Jan 2002

Hill Kathleen A, Sommer Steve S

Abstract excerpt

The p53 gene is mutated in about half of all tumors. The p53 gene can be used as a "mutagen test," that is, the relative frequencies of the different types of mutation can be used as an epidemiological tool to explore the contribution of exogenous mutagens vs. endogenous processes in particular cancers. p53 has been used as a mutagen test in breast cancer. Surprisingly, the pattern of p53 mutations differs among...

Topics

Breast Neoplasms
Cohort Studies
DNA, Neoplasm
Female
Genes, p53
Humans
Mutagenicity Tests
Mutation

Source

Open in PubMed

Identifiers

PMID: 11921192
DOI: 10.1002/em.10065

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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