Article
Molecular methods for the detection of mutations.
Teratogenesis, carcinogenesis, and mutagenesis - 1 Jan 2000
Monteiro C, Marcelino L A, Conde A R, Saraiva C, Giphart-Gassler M, De Nooij-van Dalen A G, Van Buuren-van Seggelen V, Van der Keur M, May C A, Cole J, Lehmann A R, Steinsgrimsdottir H, Beare D, Capulas E, Armour J A
Abstract excerpt
We report the results of a collaborative study aimed at developing reliable, direct assays for mutation in human cells. The project used common lymphoblastoid cell lines, both with and without mutagen treatment, as a shared resource to validate the development of new molecular methods for the detection of low-level mutations in the presence of a large excess of normal alleles. As the "gold standard, " hprt...
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