Article
Comparison between p53 protein measurements using the luminometric immunoassay and immunohistochemistry with detection of p53 gene mutations using cDNA sequencing in human breast tumors.
International journal of cancer - 21 Aug 1998
Norberg T, Lennerstrand J, Inganäs M, Bergh J
Abstract excerpt
The p53 mutational status of 226 representative primary breast cancer samples, derived from a population-based cohort, was analyzed using cDNA-based sequencing. The results were compared with those obtained with immunohistochemistry (IHC) on microwave-treated paraffin sections and the p53 specifi...
Topics
- Breast Neoplasms
- DNA, Complementary
- Genes, p53
- Humans
- Immunoassay
- Immunohistochemistry
- Mutation
- Sequence Analysis, DNA
- Tumor Suppressor Protein p53