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Most spontaneous tumors in a mouse model of Li-Fraumeni syndrome do not have a mutator phenotype.

Carcinogenesis - 1 Sept 2006

Hill Kathleen A, Buettner Victoria L, Heidt Analeah, Chen Lin-Ling, Li Wenyan, Gonzalez Kelly D, Wang Ji-Cheng, Scaringe William A, Sommer Steve S

Abstract excerpt

Mutations are the substrate of cancer. Yet, little is known about the degree and nature of mutations in tumors because measurement of mutation load in tumors and normal tissues was generally not possible until the advent of transgenic mouse mutation detection systems. Herein, we present the first analysis of mutation frequency and pattern in thymic tumors from a mouse model of Li-Fraumeni syndrome (p53+/- murine...

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PMID: 16597646
DOI: 10.1093/carcin/bgl029

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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