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Article

The proto-oncoprotein c-Fos negatively regulates hepatocellular tumorigenesis.

Oncogene - 2 Oct 2003

Mikula Mario, Gotzmann Josef, Fischer Alexandra N M, Wolschek Markus F, Thallinger Christiane, Schulte-Hermann Rolf, Beug Hartmut, Mikulits Wolfgang

Abstract excerpt

Hepatocytes adopt an invasive and metastatic phenotype caused by the cooperation of transforming growth factor (TGF)-beta and oncogenic Ha-Ras. In the initial phase of this process, c-Fos is rapidly induced by TGF-beta, but then decreases to undetectable levels. Here, we investigated the functional implications of c-Fos activation and its contribution to hepatocellular tumorigenesis. By employing conditional...

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PMID: 14555986
DOI: 10.1038/sj.onc.1206781

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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