Article
c-fos is required for malignant progression of skin tumors.
Cell - 8 Sept 1995
Saez E, Rutberg S E, Mueller E, Oppenheim H, Smoluk J, Yuspa S H, Spiegelman B M
Abstract excerpt
The proto-oncogene c-fos is a major nuclear target for signal transduction pathways involved in the regulation of cell growth, differentiation, and transformation. Using the multistep skin carcinogenesis model, we have directly tested the ability of c-fos-deficient mice to develop cancer. Upon tr...
Topics
- Animals
- Cell Differentiation
- Cell Transformation, Neoplastic
- Epidermal Cells
- Gene Expression
- Genes, fos
- Genes, ras
- Keratinocytes
- Keratins
- Mice
- Mice, Nude
- Mice, Transgenic
- Mutation