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Article

Transforming growth factor β regulates clusterin gene expression via modulation of transcription factor c‐Fos

15 Jul 1999

Abstract excerpt

Transforming growth factor-beta (TGFbeta) induces gene expression of the glycoprotein clusterin in a variety of cell types via a consensus AP-1 binding site. Here, we demonstrate, by supershift analysis, that JunB, JunD, Fra1, Fra2, and c-Fos bound to AP-1 but that prior treatment of the cells with TGFbeta reduced dramatically c-Fos binding, suggesting that c-Fos might be playing a negative regulatory role in...

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PMID: 10406964
DOI: 10.1046/j.1432-1327.1999.00533.x

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